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Title: Spermitin: A Novel Mitochondrial Protein in Drosophila Spermatids.
Name(s): Chen, Jieyan, author
Megraw, Timothy, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2014
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Mitochondria, important energy centers in the cell, also control sperm cell morphogenesis.Drosophila spermatids have a remarkably large mitochondrial formation called the nebenkern. Immediately following meiosis during sperm development, the mitochondria in the spermatid fuse together into two large aggregates which then wrap around one another to produce the spherical nebenkern: a giant mitochondrion about 6 micrometers in diameter. The fused mitochondria play an important role in sperm tail elongation by providing a structural platform to support the elongation of sperm cells. We have identified a novel testis-specific protein, Spermitin (Sprn), a protein with a Pleckstrin homology-like (PH) domain related to Ran-binding protein 1 at its C-terminus. Fluorescence microscopy showed that Sprn localizes at mitochondria in transfected Kc167 cells, and in the nebenkern throughout spermatid morphogenesis. The role of Sprn is unclear, as sprn mutant males are fertile, and have sperm tail length comparable to the wild-type.
Identifier: FSU_migr_biomed_faculty_publications-0049 (IID), 10.1371/journal.pone.0108802 (DOI)
Keywords: Drosophila, mitochondrion, spermatogenesis
Note: Article of record published in PLoS One. © 2014 Chen, Megraw. This is an open-access article distributed under the terms of the Creative'>">Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Chen JV, Megraw TL. (2014). Spermitin: a novel mitochondrial protein in Drosophila spermatids. PLoS One. 9(9):e108802. doi: 10.1371/journal.pone.0108802.
Subject(s): Cytology
Developmental biology
Medical sciences
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Department of Biomedical Sciences Faculty Publications.
Is Part Of: Spermitin: A Novel Mitochondrial Protein in Drosophila Spermatids.
Issue: 9, 9

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Chen, J., & Megraw, T. (2014). Spermitin: A Novel Mitochondrial Protein in Drosophila Spermatids. Spermitin. Retrieved from