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Chromatin Structural Changes in the Innate Immune Response

Title: Chromatin Structural Changes in the Innate Immune Response.
Name(s): Welch, Alexandra, author
Department of Biological Science
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2014
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Eukaryotic nucleosomes have critical regulatory roles in mediating access to DNA. Differential regulation of nucleosome distribution is necessary for generating a rapid response to pathogens in the innate immune response and other stimuli. However, this genomic reorganization event is largely uncharacterized. Our lab has proposed that early, widespread, and transient reorganization of the genomic structure potentiates the appropriate responses of the cell to insult. We have identified chromatin structural changes in THP-1 human macrophage-like cell line induced by S. aureus stimulation. We measured nucleosome distribution high temporal resolution through the course of infection at more than 800 inflammation and immunity related genes. Herein we show that S. aureus indeed does induce rapid widespread changes in nucleosome distribution. This work supports a new model in which widespread changes potentiate a robust immune response.
Identifier: FSU_migr_uhm-0416 (IID)
Keywords: Chromatin, Nucleosome, Innate Immune Response, MNase
Submitted Note: A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2014.
Date of Defense: April 18, 2014.
Subject(s): Biology
Communicable diseases
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Welch, A. (2014). Chromatin Structural Changes in the Innate Immune Response. Retrieved from