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Investigating the Involvement of the Helicase, Belle, with RNA Silencing

Title: Investigating the Involvement of the Helicase, Belle, with RNA Silencing.
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Name(s): Sabusap, CarleenMae, author
Department of Biological Science
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The mobile and self-perpetuating nature of transposons allows them to impact organisms in a polarized manner: as an evolutionary force in increasing genome size and as molecular parasites whose activities may lead to potentially deleterious mutations and other harmful effects such as DNA doublestrand breaks. In Homo sapiens, mobile elements constitute about 45% of the sequence content, DNA transposons 3%, and retrotransposons 40%. Despite this overwhelming presence in the genome and across species, mobile elements do not run rampant and unchecked. Post-transcriptional gene silencing or RNA interference (RNAi) provides the natural safeguard against destructive viral invasions and TEs. In both somatic and germline cells, the piRNA pathway is the principle line of defense against transposons and other mobile genetic elements. Compared to the microRNA and siRNA pathways, little is known about the fundamental molecular instruments working behind the piRNA pathway to ensure genetic stability. Distinguishing a role for Belle in the piRNA pathway will bring us another step closer to understanding the complex mechanism for the genome's self-defense.
Identifier: FSU_migr_uhm-0112 (IID)
Keywords: RNA silencing, Belle, piRNA pathway, nuage, transposable elements
Submitted Note: A Thesis submitted to the Department of Biology in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2013.
Date of Defense: July 27, 2012.
Subject(s): Biology
Developmental biology
Genetics
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0112
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Sabusap, C. M. (2012). Investigating the Involvement of the Helicase, Belle, with RNA Silencing. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0112