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Analysis of Chromatin Structure Indicates a Role for Fluoxetine in Altering Nucleosome Distribution

Title: Analysis of Chromatin Structure Indicates a Role for Fluoxetine in Altering Nucleosome Distribution.
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Name(s): Gracia, Ely, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: An interesting stimulus for chromatin structural changes is the generic and popular anti-depressant drug Fluoxetine, commonly known as Prozac. Generally accepted as a Selective Serotonin Reuptake Inhibitors (SSRI's), recent work has emerged suggesting that this antidepressant also functions as a Histone Deaceylase Inhibitors (HDIs). Studies have also come out indicating that Fluoxetine acts as an immunosuppressant drug. Treatment with Fluoxetine is believed to reduce the over-activation of the immune system associated with depression. We have used an innovative microarray technology to measure changes in nucleosomal positioning that stem from Fluoxetine treatment. With the use of the microarray, we were able to show that Fluoxetine regulated chromatin structure, that Fluoxetine induced nucleosomal changes show time-dependent kinetics, and targeted genes responsible for the regulation of immune system processes. These results give new and important insights into non-SSRI roles of this highly prescribed class of drugs.
Identifier: FSU_migr_uhm-0087 (IID)
Submitted Note: A Thesis submitted to the Department of Biological Sciences in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2012.
Date of Defense: April 17, 2012.
Subject(s): Biology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0087
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Gracia, E. (2012). Analysis of Chromatin Structure Indicates a Role for Fluoxetine in Altering Nucleosome Distribution. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0087