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Effects of Nicotine on Neurotrophic Factor Expression in the Adult Male Zebra Finch

Title: The Effects of Nicotine on Neurotrophic Factor Expression in the Adult Male Zebra Finch.
Name(s): Peoples, Jessica, author
Chemistry and Biochemistry
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: This thesis examines the effects of nicotine on the expression of Brain- Derived Neurotrophic Factor (BDNF) in the brain of adult male zebra finches (Taeniopygia guttata) under isolated and social housing conditions. BDNF, which is essential for survival, growth, and neuroplasticity of neurons, is significantly decreased in patients with affective disorders, such as depression and schizophrenia. A significant number of these patients use tobacco products, which induce an increase in plasma BDNF levels. Isolated rodents exposed to nicotine showed an increase in central BDNF levels. The zebra finch is an established model to study cognitive functioning, and as such we examined how nicotine interacts with BDNF expression in zebra finch brain areas involved in cognitive functioning such as the song nuclei and the hippocampal area. Adult male zebra finches were exposed to nicotine and the expression of BDNF was examined between isolated and social housed male zebra finches, using immunocytochemistry. The results show that the housing conditions did not have an effect on the expression of BDNF in the examined song nuclei or the hippocampal area. However, nicotine induced an increased expression of BDNF in the song nuclei HVC, RA (Robust Nucleus of the Archistriatum), and Area X. The HVC and RA contain nicotinic acetylcholinergic receptors, which could explain our finding. Area X is involved in song learning, which is not applicable to our animals, as adult animals have a crystallized pattern. The results could be explained by the fact that Area X might be under direct control of the HVC.
Identifier: FSU_migr_uhm-0069 (IID)
Keywords: Nicotine, Zebra Finch, Brain-Derived Neurotrophic Factor
Submitted Note: A Thesis submitted to the Department of Chemistry & Biochemistry in partial fulfillment of the requirements for the degree of Honors in the Major.
Degree Awarded: Spring Semester, 2012.
Date of Defense: April 6, 2012.
Subject(s): Biochemistry
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Peoples, J. (2012). The Effects of Nicotine on Neurotrophic Factor Expression in the Adult Male Zebra Finch. Retrieved from