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Hallmark Pathology of Temporal Lobe Epilepsy

Title: Hallmark Pathology of Temporal Lobe Epilepsy: Loss of Layer III Pyramidal Neurons in the Entorhinal Cortex and its Relation to Distribution of NMDA Receptor Subunits.
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Name(s): Richardson, Max, author
Biological Science
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Neuronal loss in Layer III of the medial entorhinal cortex (MEA) is a characteristic phenomenon associated with Temporal Lobe Epilepsy. The immediately adjacent lateral entorhinal cortex (LEA) does not exhibit such loss. The current study uses indirect immunofluorescence assays in the third layer of both the medial and lateral entorhinal cortex to detect differences in protein expression of the most prevalent N-methyl-D-aspartate receptor (NMDAR) subunit isoforms in the adult cortex: the GluN1, GluN2A and GluN2B subunits. The latter two subunits confer varying levels of Ca2+ permeability and ostensibly the potential for excitotoxicity that may lead to characteristic loss of this particular population of neurons. We find that the level of GluN1 protein expression in the MEA and LEA is similar, suggesting that the number of NMDARs in the MEA and LEA is also similar, and that both GluN2A and GluN2B expression is higher in the MEA than in the LEA. These findings taken together may suggest a difference in subunit distribution and/or stoichiometry of NMDA receptors between the third layer of the MEA and LEA.
Identifier: FSU_migr_uhm-0061 (IID)
Keywords: Temporal Lobe Epilepsy; N-Methyl-D-Aspartate Receptors; Immunofluorescence
Submitted Note: A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2012.
Date of Defense: April 13, 2012.
Subject(s): Biology
Life sciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0061
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Richardson, M. (2012). Hallmark Pathology of Temporal Lobe Epilepsy: Loss of Layer III Pyramidal Neurons in the Entorhinal Cortex and its Relation to Distribution of NMDA Receptor Subunits. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0061