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Initial Characterization of Two Alpha-Helical Membrane Proteins from Mycobacterium Tuberculosis

Title: Initial Characterization of Two Alpha-Helical Membrane Proteins from Mycobacterium Tuberculosis.
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Name(s): Chase, Rose Ann, author
Cross, Timothy A., professor directing thesis
Fadool, Debra Ann, outside committee member
Logan, Timothy, committee member
Krafft, Marie E., committee member
Department of Chemistry and Biochemistry, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2007
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Rv3004 and Rv1861 are membrane proteins from Mycobacterium tuberculosis. Rv3004 is a 112 amino acid protein with one predicted transmembrane helix. Rv1861 is a 101 amino acid protein with three predicted transmembrane helices. Both proteins can be successfully labeled with 15N and expressed in high yields. Based on the NMR data, Rv3004 is a very stable protein that has very little solvent accessibility. Rv1861 is likely to be a high weight oligomer in its natural state. It is also very well structured and has two transmembrane helices oriented at a 37º tilt relative to the bilayer normal.
Identifier: FSU_migr_etd-3878 (IID)
Submitted Note: A Thesis submitted to the Department of Chemistry & Biochemistry in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Summer Semester, 2007.
Date of Defense: June 6, 2007.
Keywords: NMR, Solution NMR, Solid State NMR, Maldi-tof, Nhmfl
Bibliography Note: Includes bibliographical references.
Advisory Committee: Timothy A. Cross, Professor Directing Thesis; Debra Ann Fadool, Outside Committee Member; Timothy Logan, Committee Member; Marie E. Krafft, Committee Member.
Subject(s): Chemistry
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-3878
Owner Institution: FSU

Choose the citation style.
Chase, R. A. (2007). Initial Characterization of Two Alpha-Helical Membrane Proteins from Mycobacterium Tuberculosis. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-3878