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Towards a New Pathway for Synthesis of Taxol and Its Analogs

Title: Towards a New Pathway for Synthesis of Taxol and Its Analogs.
Name(s): Joud, Carol, author
Holton, Robert A., professor directing thesis
Krafft, Marie E., committee member
Schlenoff, Joseph, committee member
Department of Chemistry and Biochemistry, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2005
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The total synthesis of taxol has been attempted and successfully completed by many well known chemists. However, the access to analogs is still limited, and the complex structure of the ABC skeleton of taxol does not allow much flexibility for substitution. As a result, this thesis has been initiated in an attempt to find a more efficient pathway to access taxol analogs. Based on a former synthetic procedure, some studies have been undertaken to incorporate the C ring early in the synthesis. If successful, the ABC skeleton could be accessible in about 15 steps, and analogs could be formed through substitution at an early stage.
Identifier: FSU_migr_etd-3701 (IID)
Submitted Note: A Thesis submitted to the Department of Chemistry in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Fall Semester, 2005.
Date of Defense: November 14, 2005.
Keywords: Total Synthesis, Meerwein-Wagner Rearrangement, Oxy-Cope Reaction, Taxol Analogs, Taxol
Bibliography Note: Includes bibliographical references.
Advisory Committee: Robert A. Holton, Professor Directing Thesis; Marie E. Krafft, Committee Member; Joseph Schlenoff, Committee Member.
Subject(s): Chemistry
Persistent Link to This Record:
Owner Institution: FSU

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Joud, C. (2005). Towards a New Pathway for Synthesis of Taxol and Its Analogs. Retrieved from