You are here

Neuropsychological Indicators of Preclinical Alzheimer's Disease Among Depressed Older Adults

Title: Neuropsychological Indicators of Preclinical Alzheimer's Disease Among Depressed Older Adults.
32 views
6 downloads
Name(s): Collins, Nicole, author
SachsEricsson, Natalie, professor directing thesis
Carbonell, Joyce, committee member
Boot, Walter, committee member
Department of Psychology, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2011
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Depression and Alzheimer's disease (AD) occur frequently in geriatric patients, but it is difficult to identify which depressed patients are in the preclinical AD phase due to the overlapping cognitive impairment in depression and AD. Based on data from 120 depressed patients who were dementia-free and completed a range of neuropsychological tests at baseline, we predicted that measures of temporal lobe function (area affected most in early AD), but not frontal lobe function, would distinguish older depressed patients who developed AD from those who did not develop AD. We found the domain of temporal lobe function was associated with AD to a greater extent than frontal lobe function in a structural equation model (SEM). Individual tests of temporal lobe function, including Logical Memory and Word List Learning were most predictive of AD status and had the highest sensitivity in logistic regression models. At least a one standard deviation on these tests in relation to scores derived for the population based on age and education should alert the clinician to the possibility of preclinical AD and warrant closer follow-up.
Identifier: FSU_migr_etd-3498 (IID)
Submitted Note: A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Summer Semester, 2011.
Date of Defense: June 13, 2011.
Keywords: Normative Data, Dementia, Elderly
Bibliography Note: Includes bibliographical references.
Advisory Committee: Natalie SachsEricsson, Professor Directing Thesis; Joyce Carbonell, Committee Member; Walter Boot, Committee Member.
Subject(s): Psychology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-3498
Owner Institution: FSU

Choose the citation style.
Collins, N. (2011). Neuropsychological Indicators of Preclinical Alzheimer's Disease Among Depressed Older Adults. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-3498