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Lithium Protects Neurons from Deafferentation-Induced Cell Death

Title: Lithium Protects Neurons from Deafferentation-Induced Cell Death.
Name(s): Bush, Angela L., author
Hyson, Richard, professor directing thesis
Johnson, Frank, committee member
Licht, Barbara G., committee member
Department of Psychology, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2004
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Approximately 20-30% of neurons in the avian cochlear nucleus, nucleus magnocellularis (NM) die following deafferentation (i.e., deafness produced by cochlea removal) and there is no known treatment to prevent this cell death. Cell death is generally accepted to be a highly regulated process involving a variety of pro-survival and pro-death molecules. One treatment that has been shown to modify the expression of these molecules is chronic administration of lithium, which has been shown to reduce neuronal death in animal models of neurodegenerative disorders and death induced by ischemia. Cell death following deafferentation has been shown to share some, but not all of the molecular events observed following other death-inducing insults. The present experiment examined whether lithium treatment can protect neurons from deafferentation-induced cell death. Post-hatch chicks were treated with LiCl or saline for 17 consecutive days, beginning on the day of hatching. On the 17th day, a unilateral cochlea ablation was performed to produce cell death on one side of the brain. Chicks were then allowed to survive for 5 days, brains were sectioned coronally, stained for nissl, and the NM neurons were stereologically counted on opposite sides of the same brain. Birds treated with lithium prior to cochlea removal showed only 9% cell death in the deafferented NM (n=8) as compared to approximately 22% cell death observed in the saline treated controls (n=8). Lithium did not affect cell number on the intact side of the brain. We hypothesize that the reliable neuroprotective effect of lithium may result from an up-regulation of pro-survival molecules in NM neurons.
Identifier: FSU_migr_etd-2716 (IID)
Submitted Note: A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for the degree of Master’S of Science.
Degree Awarded: Fall Semester, 2004.
Date of Defense: November 3, 2004.
Keywords: Neuroprotection, Cell Death
Bibliography Note: Includes bibliographical references.
Advisory Committee: Richard Hyson, Professor Directing Thesis; Frank Johnson, Committee Member; Barbara G. Licht, Committee Member.
Subject(s): Psychology
Persistent Link to This Record:
Owner Institution: FSU

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Bush, A. L. (2004). Lithium Protects Neurons from Deafferentation-Induced Cell Death. Retrieved from