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Neuroprotective Effects of Lithium in Deafferentation-Induced Cell Death of Chick Cochlear Nucleus Neurons

Title: The Neuroprotective Effects of Lithium in Deafferentation-Induced Cell Death of Chick Cochlear Nucleus Neurons.
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Name(s): Bush, Angela L. (Angela Lizette), 1979-, author
Hyson, Rick, professor directing dissertation
Chase, Bryant, outside committee member
Houpt, Thomas, committee member
Johnson, Frank, committee member
Licht, Barbara, committee member
Department of Psychology, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2007
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The avian brainstem serves as a useful model to answer the question of how afferent activity influences viability of target neurons. Approximately 20-30% of neurons in the avian cochlear nucleus, nucleus magnocellularis (NM) die following deafferentation (i.e., deafness produced by cochlea removal). We have recently shown that chronic treatments of lithium increase neuronal survival following deafferentation. The mechanism of this neuroprotective effect is unknown, but one possibility is that lithium increases the expression of neuroprotective molecules. We have shown that the neuroprotective protein Bcl-2, is upregulated in NM neurons following lithium treatment. Interestingly, Bcl-2 mRNA (but not protein) is upregulated in a subpopulation of NM neurons following deafferentation. In both cases, it is not known what sequence of events leads to the upregulation of Bcl-2. The present experiments examine changes in molecules known to regulate Bcl-2 expression to determine whether similar factors are involved in the regulation observed following lithium administration and following deafferentation. Although Bcl-2 expression may be an important contributor to neuronal survival, it is possible that lithium is neuroprotective through its influence on other molecules. To begin to identify the mechanism of lithium's neuroprotective effect, we also determined where in the cell death cascade lithium is having its effect.
Identifier: FSU_migr_etd-2711 (IID)
Submitted Note: A Dissertation submitted to the Department of Psychology in partial fulfillment of the requirements for the degree of Doctor of Philosophy..
Degree Awarded: Fall Semester, 2007.
Date of Defense: September 7, 2007.
Keywords: Chick, Cell Death, Auditory, Lithium Neuroprotection, bcl-2
Bibliography Note: Includes bibliographical references.
Advisory Committee: Rick Hyson, Professor Directing Dissertation; Bryant Chase, Outside Committee Member; Thomas Houpt, Committee Member; Frank Johnson, Committee Member; Barbara Licht, Committee Member.
Subject(s): Psychology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-2711
Owner Institution: FSU

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Bush, A. L. (A. L. ). (2007). The Neuroprotective Effects of Lithium in Deafferentation-Induced Cell Death of Chick Cochlear Nucleus Neurons. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-2711