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Differentiation of Obsessive-Compulsive, Anxiety Disordered and Non-Disordered Individuals by Variation in the Promoter Region of the Serotonin Transporter Gene

Title: Differentiation of Obsessive-Compulsive, Anxiety Disordered and Non-Disordered Individuals by Variation in the Promoter Region of the Serotonin Transporter Gene.
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Name(s): Perez, Marisol, author
Joiner, Thomas E., Jr., professor directing dissertation
Houpt, Thomas A., outside committee member
Taylor, Jeanette, committee member
Berler, Ellen, committee member
Johnson, Frank, committee member
Department of Psychology, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2004
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Obsessive-Compulsive Disorder (OCD) is a severe and debilitating anxiety disorder with relatively little known about its etiology. The serotonin-transporter gene is one likely place to start investigating the genotypes associated with OCD, given the efficacy of serotonin re-uptake inhibitors for treating OCD. It was predicted that individuals with OCD would have higher frequencies of the s/s allele when compared to non-disordered individuals. The allelic frequency of the OCD group was also compared to an anxiety group consisting of mostly panic disordered individuals. As an exploratory analysis, individuals were also assessed for Obsessive-Compulsive Personality Disorder (OCPD) and their allelic frequencies were also compared to non-disordered individuals. In total there were 198 individuals genotyped, of which 30 had OCD with no other comorbidity, 26 had an anxiety disorder other than OCD, and 17 had OCPD. Consistent with the hypothesis, analyses revealed that there were higher frequencies of the s/s allele among OCD individuals when compared to non-disordered controls. There were no differences in allelic frequencies between the OCD group and the Anxiety disordered group. Finally, there were no differences in allelic frequencies on the serotonin transporter gene between the OCPD group and the non-disordered control group.
Identifier: FSU_migr_etd-2031 (IID)
Submitted Note: A Dissertation Submitted to the Department of Psychology in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy.
Degree Awarded: Summer Semester, 2004.
Date of Defense: June 21, 2004.
Keywords: Serotonin Transporter, Genes, OCD
Bibliography Note: Includes bibliographical references.
Advisory Committee: Thomas E. Joiner, Jr., Professor Directing Dissertation; Thomas A. Houpt, Outside Committee Member; Jeanette Taylor, Committee Member; Ellen Berler, Committee Member; Frank Johnson, Committee Member.
Subject(s): Psychology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-2031
Owner Institution: FSU

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Perez, M. (2004). Differentiation of Obsessive-Compulsive, Anxiety Disordered and Non-Disordered Individuals by Variation in the Promoter Region of the Serotonin Transporter Gene. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-2031