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Effect of Social Isolation on Anxiety-Related Behaviors and Associated Hormonal and Neuronal Activation in Male Prairie and Meadow Voles

Title: The Effect of Social Isolation on Anxiety-Related Behaviors and Associated Hormonal and Neuronal Activation in Male Prairie and Meadow Voles.
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Name(s): Stowe, Jennifer R., author
Wang, Zuoxin, professor directing thesis
Rashotte, Michael E., committee member
Licht, Barbara G., committee member
Department of Psychology, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2003
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Monogamous prairie (Microtus ochrogaster) and promiscuous meadow (M. pennsylvanicus) voles exhibit different social behaviors in the wild. In a first experiment, it was determined that large species differences existed in elevated plus maze (EPM) behavior, plasma corticosterone (CORT), and neuronal activation in several limbic structures. Acute (24hr) and chronic (2wk) social isolation biphasically altered prairie vole behavior on the EPM, but no differences were seen in meadow vole behavior. Social isolation also increased Fos-immunoreactive (Fos-ir) cells differentially in select brain regions of male prairie and meadow voles. In a second experiment, social isolation alone increased the basal level of Fos-ir in the medial preoptic area, anterior and ventromedial hypothalamus following acute social isolation, while chronic isolation decreased Fos-ir in the lateral septum of prairie voles. A third experiment examined a time course for CORT following the EPM in prairie voles, and it was established that CORT levels peaked at 20min post-EPM test. Taken together, our data indicate species differences in behavior on the EPM that are further altered by social isolation. In prairie voles, increased open arm activity does not correlate with increased CORT levels, which suggests that EPM test behavior may not indicate changes in anxiety in this glucocorticoid resistant species. EPM behavior alone also did not alter neuronal activation. However, species-specific patterns of neuronal activation in limbic structures did occur when social isolation was coupled with the EPM test.
Identifier: FSU_migr_etd-1550 (IID)
Submitted Note: A Thesis Submitted to the Department of Psychology in Partial Fulfillment of the Requirements for the Degree of Master of Science.
Degree Awarded: Spring Semester, 2003.
Date of Defense: April 23, 2003.
Keywords: Social Isolation, Fos-immunoreactive (Fos-ir) Cells
Bibliography Note: Includes bibliographical references.
Advisory committee: Zuoxin Wang, Professor Directing Thesis; Michael E. Rashotte, Committee Member; Barbara G. Licht, Committee Member.
Subject(s): Psychology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-1550
Owner Institution: FSU

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Stowe, J. R. (2003). The Effect of Social Isolation on Anxiety-Related Behaviors and Associated Hormonal and Neuronal Activation in Male Prairie and Meadow Voles. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-1550