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Metabolic and Behavioral Effects of Zinc Deficiency in Rats

Title: Metabolic and Behavioral Effects of Zinc Deficiency in Rats.
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Name(s): Evans, Stephanie Anne, author
Levenson, Cathy W., professor directing thesis
Overton, J. Michael, committee member
Ouimet, Charles, outside committee member
Department of Nutrition, Food, and Exercise Science, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2003
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Disruptions in the regulation of food intake and metabolism can result in obesity or anorexia. It is clear that zinc deficiency results in anorexia and previous research suggests the existence of alterations in energy efficiency and metabolism. Zinc deficiency results in changes in neuropeptides that regulate energy intake and expenditure. Numerous diagnostic conditions also result in anorexia and wasting, similar to that of zinc deficiency. However, the mechanism underlying these abnormalities remains unknown, and the behavioral and metabolic effects of zinc deficiency have not been fully established. Therefore, the purpose of this work is to fully characterize the behavioral and metabolic consequences of zinc deficiency and its association with anxiety, and to suggest mechanisms underlying the anorexia associated with zinc deficiency and other clinical conditions. Despite differences in locomotor activity between zinc deficient(ZD, zinc, ad lib) and pair-fed (PF, 28 ppm zinc, amount consumed by ZD), there were no differences in MR, RQ or BMR. This suggests a greater metabolic cost of activity may exist in ZD. Contrary to previous studies, this work shows a decrease in consummatory food intake with zinc deficiency without evidence of alterations in appetitive motivational behaviors. This suggests that zinc deficiency alters the hedonic impact of food reward, but not the motivation to seek food. The data presented here also suggests an anxiogenic effect associated with zinc deficiency, which may be involved in the hedonic changes in food intake. Furthermore, this work suggests that alterations of the opioid reward system may be involved in the anorexia and anxiety-like behaviors produced by zinc deficiency.
Identifier: FSU_migr_etd-0436 (IID)
Submitted Note: A Thesis submitted to The Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the Requirements for the degree of Master of Science.
Degree Awarded: Degree Awarded: Spring Semester, 2003.
Date of Defense: Date of Defense: April 1, 2003.
Keywords: Zinc Deficiency, Metabolism
Bibliography Note: Includes bibliographical references.
Advisory committee: Cathy W. Levenson, Professor Directing Thesis; J. Michael Overton, Committee Member; Charles Ouimet, Outside Committee Member.
Subject(s): Nutrition
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-0436
Owner Institution: FSU

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Evans, S. A. (2003). Metabolic and Behavioral Effects of Zinc Deficiency in Rats. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-0436