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Relationship of Oral Contraceptive Use with Substrate Utilization in Regularly Active Females during Moderate Intensity Exercise

Title: The Relationship of Oral Contraceptive Use with Substrate Utilization in Regularly Active Females during Moderate Intensity Exercise.
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Name(s): Anderson, Elyzabeth A., author
Dorsey, Jodee, professor directing dissertation
Lynn, Susan, outside committee member
Haymes, Emily M., committee member
Department of Nutrition, Food, and Exercise Science, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2005
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Whole body lipid and carbohydrate utilization during moderate intensity exercise was examined in eumenorrheic women using oral contraceptive agents (OCA) (n=10) compared to women who were not using OCA (n=9) during the high and low hormone phases of the menstrual cycle. High hormone phases were considered to be the mid-luteal phase of non-OCA users, or the third week of active pill phase of OCA users. Low hormone phases were the placebo pill phase for OCA users or the early follicular phase of non-OCA users. Subjects were tested in an overnight fasted state. The two exercise trials consisted of cycling for one hour at 65% of peak oxygen consumption on an electronically braked cycle ergometer. Substrate utilization was assessed at rest and at 15 minute intervals during exercise using respiratory gas analysis and measurements of serum glycerol and free fatty acids and plasma glucose. Measurements of plasma estradiol and progesterone at rest and plasma insulin at rest, 30, and 60 minutes were also performed. The only significant difference noted in lipid utilization was a lower resting respiratory exchange ratio (RER), during the high hormone phases compared to the low hormone phases of the menstrual cycle for both OCA and non-OCA users. A main effect of ovarian hormones and insulin was also found, in that higher circulating insulin levels were noted in the high hormone phases when compared to the low hormone phases, regardless of OCA use. There were also significant changes over time for substrate utilization during exercise, as expected, but there were not any significant differences for OCA use or menstrual cycle phase. These findings suggest that there is no need to omit female subjects using OCA from studies examining energy substrate utilization during moderate intensity exercise.
Identifier: FSU_migr_etd-0195 (IID)
Submitted Note: A Dissertation submitted to the Department of Nutrition, Food, and Exercise Science in partial fulfillment of the Requirements for the degree of Doctor of Philosophy.
Degree Awarded: Degree Awarded: Spring Semester, 2005.
Date of Defense: Date of Defense: August 5, 2004.
Keywords: Female Athlete, Lipid Oxidation, Menstrual Cycle, Substrate Utilization, Oral Contraceptives
Bibliography Note: Includes bibliographical references.
Advisory committee: Jodee Dorsey, Professor Directing Dissertation; Susan Lynn, Outside Committee Member; Emily M. Haymes, Committee Member.
Subject(s): Food
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-0195
Owner Institution: FSU

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Anderson, E. A. (2005). The Relationship of Oral Contraceptive Use with Substrate Utilization in Regularly Active Females during Moderate Intensity Exercise. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-0195